羅敏敏博士 - 科學研究 - 北京生命科學研究所

羅敏敏博士

北京生命科學研究所資深研究員

Minmin Luo, Ph.D. Investigator, NIBS, Beijing, China

Phone：010-80726688

Fax： 010-80723342

E-mail：luominmin@nibs.ac.cn

教育經歷

Education

2000	美國賓夕法尼亞大學神經學博士
	Ph. D. Neuroscience, 2000, University of Pennsylvania, USA
1997	美國賓夕法尼亞大學計算機科學碩士
	M.S. Computer Science, 1997，University of Pennsylvania, USA
1995	北京大學心理學學士
	B.S. Psychology，1995，Peking University, China

工作經歷

Professional Experience

2013-present

北京生命科學研究所資深研究員

Investigator, National Institute of Biological Sciences, Beijing, China

2010-2013

北京生命科學研究所高級研究員

Associate Investigator in the National Institute of Biological Sciences, Beijing, China

2005-2010

北京生命科學研究所研究員

Assistant Investigator in the National Institute of Biological Sciences, Beijing, China

Recipient of HFSP Young Investigators Award (2006-2009) and NSFC Young Investigator Award (2006-2009)

2004 -2005

中科院神經科學研究所研究員

Investigator in the Institute of Neuroscience of Chinese Academy of Sciences

2000-2004

杜克大學神經生物學系博士后

Postdoctoral Fellow with Lawrence C. Katz in HHMI and the Department of Neurobiology, Duke University, USA

Recipient of

研究興趣

獎賞與懲罰驅使動物接近或逃避、產生快樂與痛苦、并指導學習與記憶形成。獎賞與懲罰關乎動物的生死與種系繁衍、并在人類的日常生活中影響情緒與情感。小鼠與人有類似的神經環路，并對獎賞與懲罰有相似的行為反應。我們實驗室以轉基因小鼠為模型，研究哺乳動物處理獎賞與懲罰的神經環路機制，特別是中縫背核及內側韁核兩個腦區及相連的神經環路的作用。我們運用電生理和光學成像，從清醒小鼠中記錄特定類型神經元的在獎賞與懲罰相關行為中的反應特點。繼而運用光遺傳學及化學遺傳學手段，檢測激活、抑制、損毀相關神經元對于行為的影響。我們也利用全細胞膜片鉗和光學成像等手段，探索不同藥物及細胞信號轉導途徑在獎賞與懲罰行為中的作用及分子細胞機制。腦內處理獎賞與懲罰的神經環路異常導致多種人類精神疾病，包括抑郁、精神分裂、藥物成癮等。因此，我們的工作不僅有助于理解與獎賞與懲罰相關行為的神經生物學基礎，亦可具有臨床意義。

Reward and punishment motivate animal behaviors, produce the feelings of pleasure and disappointment, and guide learning and memory formation. They are a matter of life and death for an individual as well as the species, and affect mood and emotion in our daily life. Mice share with humanskey features of reward- and punishment-related behaviors and theunderlying neural pathways. Using genetically modified mice as the model system, my laboratory studies how neural circuits organize behavioral responses to reward and punishment. At present we focus on the dorsal raphe nucleus and the medial habenula, as well as their interconnected brain areas. Using electrophysiological and optical approaches, we record the activity patterns of genetically identified neuron types from behaving mice. We also combine optogenetics and chemogenetics to examine how stimulation, inhibition, or lesion of specific neurons affects animal behaviors. Finally, we carry out whole-cell patch recordings from brain slices to study the effects of drugs and cellular signal transduction pathways. The dysfunctions of reward and punishment processing are associated with several devastating psychiatric disorders, such as depression, schizophrenia, and drug addiction. Thus, our study not only help understand the neurobiological basis of some fundamental animal behaviors but also may facilitate clinical efforts toward the cure of mental diseases.

論文發表

1.	Wang D, He X, Zhao Z, Feng Q, Lin R, Sun Y, Ding T, Xu F^CA, Luo M^CA, Zhan C^CA (2015) Whole-brain mapping of the direct inputs and axonal projections of pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. *Front. Neuroanat.* \|DOI 10.3389/fnana.2015.00040
2.	Guo Q, Wang D,He X,Feng Q, Lin R, Xu F, Fu L, Luo M^CA (2015)Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum. *PLOS One* DOI: 10.1371/journal.pone.0123381.
3.	Zhou J, Jia C, Feng Q, Bao J, Luo M^CA (2015) Prospective coding ofdorsal raphe rewardsignals by the orbitofrontal cortex. *J Neurosci* 35:2717-2730.
4.	Liu Z^, Zhou J^, Li Y, Hu F, Wang D, Lu Y, Ma M, FengQ, Zhang J, ZengJ, Bao, KimJ, ChenZ, MestikawySE, Luo M^CA (2014) Dorsal raphe neurons signal reward through 5-HT and glutamate. *Neuron*81:1360–1374. (Faculty1000 Prime)
5.	Han Y, Shi Y-F, Xi W, Zhou R, Tan Z-B, Wang H, Li X-M, Chen Z, Feng G, Luo M, Huang Z-L, Duan S^CA, Yu Y-Q^CA (2014) Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions.Current Biology24:693–698
6.	Wang S, Tan Y, Zhang J, Luo M^CA (2013) Pharmacogenetic activation of midbrain dopamine neurons produces hyperactivity. *Neurosci Bulletin* 29:517-524.
7.	Zhan C^CA, Zhou J, Feng Q, Zhang J, Lin S, Bao J, Wu P, Luo M^CA (2013) Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively.J Neurosci33:3624 –3632. (Faculty1000 Prime)
8.	Hu F, Ren J, Zhang J, Zhong W, Luo M^CA (2012) Atrial natriuretic peptide blocks synaptic transmission by activating Phosphodiesterase 2Aand eliminating basal PKA activity in presynaptic terminals. *PNAS* 109: 17681–17686.(Faculty1000 Prime)
9.	Ma M, Luo M^CA (2012) Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb. *J Neurosci*32:10105-10116. (TWIJ feature article).
10.	Luo M^CA (2011) Long-range intracortical excitation shapes olfactory processing. *Neuron* 72:1-3. (Invited preview).
11.	Gong R^, Ding C^, Hu J^, Lu Y, Liu F, Mann E, Xu F, Cohen MB and Luo M^CA(2011) Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science* 333:1642-1646.
12.	Zhao S, Ting JT, Atallah HE, Qiu L, Tan J, Gloss B, Augustine GJ, Deisseroth K, Luo M, Graybiel AM, Feng G^CA (2011) Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. *Nature Methods* 8:745-752.
13.	Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G, Luo M^CA (2011) Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. *Neuron* 69:445-452. (featured with cover; Faculty1000 Prime)
14.	Zhan C, Luo M^CA (2010) Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. *J Neurosci* 30:16662–16672.
15.	Han J, Luo M^CA (2010) Loss of CO₂ sensing by the olfactory system of CNGA3 knockout mice. *Curr Zoology* 56: 793?799.
16.	Gao L, Hu J, Zhong C, Luo M^CA (2010) Integration of CO₂ and odorant signals in the mouse olfactory bulb. *Neuroscience* 170:881–892.
17.	Tan J, Savigner A, Ma M, and Luo M^CA (2010) Odor information processing by the olfactory bulb analyzed in gene-targeted mice. *Neuron* 65:912-926. (featured with video abstract)
18.	Luo M^CA, Sun L, and Hu J (2009) Neural detection of gases—carbon dioxide, oxygen—in vertebrates and invertebrates. *Curr Opinion Neurobiol*19：354-361.
19.	Sun L, Wan H, Hu J, Han J, Matsunami H, and Luo M^CA (2009) Guanylyl cyclase-D in the olfactory CO₂ neurons is activated by bicarbonate. *PNAS* 106:2041-2046.
20.	Qin C, Luo M^CA(2009) Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula. *Neuroscience*161:827-37
21.	Fan S, Luo M^CA (2009) The organization of feedback projections in a pathway important for processing pheromonal signals. *Neuroscience*161:489-500
22.	Yan Z, Tan J, Qin C, Lu Y, Ding C, and Luo M^CA (2008) Precise circuitry links bilaterally symmetric olfactory maps. *Neuron* 58:613–624. (featured with a preview)
23.	Bian X, Yanagawa Y, Chen WR, and Luo M^CA (2008) Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala. *J Neurophysiol* 99:77-86.
24.	Luo M^CA (2008) The Necklace Olfactory System in Mammals. *J Neurogenetics*22:229-238.
25.	Hu J^, Zhong C^, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, and Luo M^CA (2007) Detection of near-atmospheric concentrations of CO₂ by an olfactory subsystem. *Science* 317:953-957.
26.	Grosmaitre X, Santarelli LC, Tan J, Luo M, and Ma M^CA (2007) Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors. Nature Neurosci 10: 348-354.
27.	Luo, M^CAand Katz LC (2004) Encoding pheromones by the mammalian vomeronasal system. *Curr Opinion Neurobiol* 14:428-34.
28.	Luo, M^CA, Fee, MS, and Katz, LC (2003) Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. *Science* 299:1196-1201 (full article with cover and News and Views; Faculty 1000 recommendation).
29.	Luo, M and Perkel, DJ (2002) Intrinsic properties and synaptic input for neurons within an avian motor thalamic nucleus during the phase crucial for song learning. *J Neurophysiol* 88:1903-1914.
30.	Luo, M^CA and Katz, LC (2001) Response correlation maps of neurons in the mammalian olfactory bulb. *Neuron* 32:1165-1179.
31.	Luo, M, Ding, L, and Perkel, DJ (2001) An avian basal ganglia pathway essential for vocal learning forms closed topographic loops. *J Neurosci* 21:6836-45.
32.	Luo, M, and Perkel, DJ (1999) A GABAergic, strongly inhibitory projection to a thalamic nucleus in the zebra finch song system. *J Neurosci* 19:6700-11.
33.	Luo, M, and Perkel, DJ (1999) Long-range GABAergic projection in a circuit essential for vocal learning. *J Comp Neurol*403: 68-84.

2013-present	北京生命科學研究所資深研究員
	Investigator, National Institute of Biological Sciences, Beijing, China
2010-2013	北京生命科學研究所高級研究員
	Associate Investigator in the National Institute of Biological Sciences, Beijing, China
2005-2010	北京生命科學研究所研究員
	Assistant Investigator in the National Institute of Biological Sciences, Beijing, China Recipient of HFSP Young Investigators Award (2006-2009) and NSFC Young Investigator Award (2006-2009)
2004 -2005	中科院神經科學研究所研究員
	Investigator in the Institute of Neuroscience of Chinese Academy of Sciences
2000-2004	杜克大學神經生物學系博士后
	Postdoctoral Fellow with Lawrence C. Katz in HHMI and the Department of Neurobiology, Duke University, USA Recipient of